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mavorixafor will improve the degree or result of codeine by impacting hepatic enzyme CYP2D6 metabolism. Contraindicated. Mavorixafor (a powerful CYP2D6 inhibitor) is contraindicated with medication which are remarkably dependent on CYP2D6 for clearance.benzhydrocodone/acetaminophen and codeine both of those improve sedation. Stay away from or Use A